1.
Org Lett
; 21(22): 9119-9123, 2019 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31686515
RESUMO
An asymmetric homoenolate cross-annulation of enals and aldehydes with high enantioselectivity is realized by NHC-catalyzed chemoselective umpolung of enals. The reaction proceeds in a highly chemoselective manner, selectively generating the conjugated Breslow intermediates from enals rather than aldehydes, enabling the homoenolate addition of enals to aldehydes in preference to competing acyl anion-mediated reactions. Enantioenriched substituted γ-butyrolactones are formed in good yields with high enantioselectivities.